Speaking to thousands of supporters in Wilkes-Barre, Pennsylvania, the ex-president accused Mr Biden of weaponizing the FBI against him.
The raid was “one of the most shocking abuses of power by any administration in American history”, Mr Trump claimed.
He was in the state to promote two Republican candidates.
Dr Mehmet Oz is running for the US Senate, and state Senator Doug Mastriano is in the race to become Pennsylvania’s next governor.
Both spoke only briefly – as always, the rally on Saturday night was really about one person: the headliner.
Mr Trump, 76, spent the first part of his nearly two-hour speech criticising the FBI search, but later returned to familiar themes: false claims that the 2020 election was stolen from him, attacks on rivals in the Democratic Party, and promises to “save our country”.
Several times, he called for people who deal drugs to receive the death penalty.
Here are four key things you need to know about Donald Trump’s rally.